Introduction
The Lille Score Calculator shows whether a patient with severe alcohol-related hepatitis is getting better on steroid treatment. After 7 days of steroids, the score tells you if the drug is working.
The score uses six things: age, albumin, bilirubin on day 0, bilirubin on day 7, creatinine, and prothrombin time (or INR). The calculator turns these into one number between 0 and 1.
A score under 0.45 means the patient is a responder. About 85% live at least 6 more months. A score of 0.45 or higher means the patient is a non-responder. About 25% live at least 6 more months. In that case, the care team may stop steroids and look at other plans, like a transplant referral.
Enter your lab values below in mg/dL, µmol/L, g/L, or g/dL. The tool converts units, shows the full math step by step, and flags values that look odd. Use it with your own clinical judgment, not in place of it.
How to use our Lille Score Calculator
Enter your patient's age, lab values from Day 0 of steroid treatment, and the bilirubin drawn on Day 7. The calculator returns the Lille score (0 to 1), tells you if the patient is a steroid responder or non-responder, shows the 6-month survival estimate, and gives a step-by-step breakdown of the math.
Age (years): Type the patient's age in whole years on the day steroids were started. If you would rather use a birth date, press "Switch to Date of Birth Entry" and pick the date. The age fills in for you.
Date of Admission / Day 0 (optional): Pick the day steroid therapy began. The tool then shows you the date the Day 7 bilirubin should be drawn. This date does not change the score.
Albumin at Day 0: Choose g/L or g/dL, then enter the serum albumin from the first day of treatment. If the patient got albumin infusions, use the value taken before the infusion.
Creatinine at Day 0: Choose mg/dL or µmol/L, then enter the creatinine. The score only checks if it is above 1.3 mg/dL (115 µmol/L), which counts as kidney trouble.
Bilirubin at Admission (Day 0): Choose mg/dL or µmol/L, then enter the total bilirubin from the day steroids started.
Bilirubin at Day 7: Enter the total bilirubin after 7 days of steroids. A drop from Day 0 is the main sign the patient is getting better. Use the "Switch both bilirubin fields" button to change both units at once.
Coagulation (PT or INR): Pick "Prothrombin Time (sec)" and enter the patient PT plus your lab's control PT. If you only have an INR, pick "INR" and enter it. The tool changes INR to seconds using a 12-second control.
Press Calculate Score to see the result, the charts, and the worked steps. Press Reset / Clear All Fields to start over with a new patient.
What Is the Lille Score?
The Lille Score shows whether a patient with severe alcohol-associated hepatitis (also called alcoholic hepatitis) is getting better on steroid medicine. It is checked after 7 full days of steroid treatment. The score is a number between 0 and 1. A lower number is better.
Why Day 7 Matters
Steroids like prednisolone can help some people with severe liver swelling from alcohol. But they do not help everyone, and they raise the risk of infection. The Lille Score uses one week of data to show who is responding. This lets the care team stop steroids early in people who are not being helped.
What the Score Uses
- Age: older age lowers the chance of a good outcome.
- Albumin on Day 0: a blood protein made by the liver. Higher is better.
- Bilirubin on Day 0 and Day 7: the yellow pigment that causes jaundice. A drop over 7 days is a good sign.
- Creatinine on Day 0: shows kidney trouble. Above 1.3 mg/dL (115 µmol/L) counts as kidney problems.
- Prothrombin time (or INR): how fast blood clots. Slow clotting means worse liver damage.
How to Read the Result
The cut-off is 0.45.
- Score under 0.45: responder. About 85% of these patients are alive at 6 months. Steroids are usually continued for the full course.
- Score 0.45 or higher: non-responder. About 25% are alive at 6 months. Doctors often stop steroids and think about other care, such as a liver transplant referral, a clinical trial, or comfort-focused care.
Things to Keep in Mind
The Lille Score is made for patients who started steroids for severe alcohol-associated hepatitis, usually those with a Maddrey Discriminant Function of 32 or more. It is not meant for other liver diseases. If a patient was given albumin through an IV, use the albumin level drawn before that infusion. Other things can raise bilirubin too, such as an infection, bile duct blockage, or another drug, so the number should always be read next to the full clinical picture. The score supports a decision. It does not make it.
Where It Comes From
The score was created by Louvet and colleagues in Lille, France, and published in 2007. It has been tested in many groups of patients since then and is used in liver care guidelines around the world.